Relation between carotid stiffness, cognitive performance and brain connectivity in a healthy middle-aged population: an observational neurophysiological cohort study with magnetoencephalography

Dagmar Nieboer, Linda Douw, Bob W van Dijk, Martijn W Heymans, Cornelis J Stam, Jos W R Twisk
2016 BMJ Open  
To cite: Nieboer D, Douw L, van Dijk BW, et al. Relation between carotid stiffness, cognitive performance and brain connectivity in a healthy middle-aged population: an observational neurophysiological cohort study with magnetoencephalography. ABSTRACT Objective: Impaired blood flow of the carotid artery can result in cognitive impairment, but how these vascular impairments lead to global cognitive disturbances is largely unknown. Problems in functional connectivity between brain areas may be
more » ... sponsible for these widespread effects. Therefore, the aim of this study was to examine the association between carotid stiffness, functional connectivity and cognitive performance in relatively young and healthy adults before clinical vascular pathology occurs.
doi:10.1136/bmjopen-2016-013441 pmid:27979838 pmcid:PMC5168642 fatcat:2u2htqyh5nd57d5w7wcypy3m6m