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Acquired Immune Deficiency Syndrome (ADIS) is a disease of the human immune system that results in a decline in the efficiency of the human immune system step by step to leave people exposed to many infections and tumours. It caused by the Human Immunodeficiency Virus (HIV). The first appeared of HIV in West Central Africa in the late 19th or early 20th century. The direct contact from personal mucus membrane or bloodstream and physical fluid (blood, vaginal semen fluid and breastfeeding milk)doi:10.26452/ijrps.v11i3.2783 fatcat:h343pm2bqjautevkuylslestsu