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Differential Roles for Cholecystokinin A Receptors in Energy Balance in Rats and Mice
Although cholecystokinin (CCK)-A receptors (CCK-AR) mediate the feeding inhibitory actions of CCK in both rats and mice, the absence of CCK-AR results in species specific phenotypes. The lack of CCK-AR in Otsuka Long-Evans Tokushima Fatty (OLETF) rats results in hyperphagia and obesity. We have suggested that demonstrated increases in meal size and elevated levels of dorsomedial hypothalamic (DMH) neuropeptide Y (NPY) gene expression may contribute to this phenotype. In contrast to OLETF rats,doi:10.1210/en.2004-0284 pmid:15123537 fatcat:oe6juohtbbb25ihbq3byordfxu