In the present investigation, petroleum ether, chloroform, ethyl acetate and methanol extracts of leaves of Ipomea pes-caprae were studied for the antibacterial and antifungal activities against Gram-positive bacteria such as Bacillus pumilus, B. subtilis, Micrococcus luteus and Staphylococcus aureus, Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia fungal strains such as Aspergillus niger, A. fumigates and A. flavus and the results are presented. The

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... n zone of inhibition for bacteria ranged from 8.5 to 25.6 mm. The minimum inhibitory concentration and minimum bactericidal concentrations were from 15.62 to 500 µg/mL and 31.25 to 1000 µg/mL respectively. The standard drug, Ciprofloxacin (10 µg/disc) was used for standard bacterial strains and recorded mean zone of inhibition ranged from 23.5 to 29.5 mm. The mean zone of inhibition for Aspergillus species ranged from 9.6 to 21.5 mm. The minimum inhibitory concentration and minimum fungicidal concentrations were from 31.25 to 500 µg /mL and 62.5 to 1000 µg/mL respectively. The standard drug, Ketoconazole (5 µg/disc) was used for Aspergillus species and recorded mean zone of inhibition ranged from 23.5 mm to 26.5 mm.