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Carbonic anhydrase (CA) is a ubiquitous enzyme catalyzing the reversible hydration of CO 2 to 3 HCO − and H + . CA plays a crucial role in CO 2 transport, acid-base balance, and in linking local acidosis to O 2 unloading from hemoglobin and also facilitates lactate shuttling across the monocarboxylate transporters (MCT). The study aimed to investigate the influence of hyperglycemia on erythrocyte carbonic anhydrase activity and lactic acid in type II diabetic patients. Method: Red blood celldoi:10.4236/jdm.2016.62017 fatcat:a2oewpimmzhrhpoi2yh3dtbgxi