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This study characterized the toxicity of Amoxicillin (AM), Erythromycin (ER) and Endosulfan (EN) to fish and mosquito larvae obtained from a certified fish farm and from Wadi Gaza. The acute toxicity tests were determined by calculating mortality percentage of fish and mosquitoes through a gradient concentration of the tested compounds. Mortality percentage, exposure time, LC 50 and LT 50 were taken as indicators of toxicity. The results showed that AM was the potent compound against fish withdoi:10.5132/eec.2015.01.03 fatcat:op4yzktw2vgrdky7z5oly7qsmq