Hippocampal volume, function and connectivity in anorexia nervosa: a systematic scoping review protocol [post]

Johanna Louise Keeler, Olivia Patsalos, Sandrine Thuret, Hubertus Himmerich, Janet Treasure
2020 unpublished
Anorexia Nervosa (AN) is a serious mental health condition, which commonly follows a chronic course, termed severe-enduring AN (SE-AN). Recent evidence suggests SE-AN may be underpinned by an interaction between genetic risk factors, the endocrinological, immune and metabolic systems and deficiencies in neural structures. One structure found to be implicated over the course of AN is the hippocampus, which similarly has shown to be affected in other psychiatric disorders. The hippocampus is
more » ... hippocampus is involved in processes such as memory and learning, as well as in the regulation of food intake. The literature on the hippocampus and AN is relatively heterogeneous and no reviews of hippocampal integrity in AN have been conducted. We will conduct a systematic scoping review of hippocampal volume, function and connectivity, as well as molecular components associated with hippocampal neurogenesis, to assess the variability in the literature and the current consensus on the hippocampus in AN.We will use methods based on the Joanna Briggs Institute scoping review methods manual. Studies of any design in populations of AN with outcomes pertaining to our inclusion criteria will be located using an electronic database search of MEDLINE (PubMed), Web Of Science and PsychINFO. Two reviewers will independently screen titles, abstracts and full-texts and chart data of eligible studies. Study characteristics will be summarised during data analysis. Reported outcomes will include main study findings and methodology.
doi:10.31219/osf.io/b64m7 fatcat:xuiqdtncnjg6nhyvb3pbfynhi4