Adrenomedullin: A Novel Therapy for Intractable Crohn's Disease with a Loss of Response to Infliximab

Shinya Ashizuka, Nobuko Kuroishi, Koji Nakashima, Haruhiko Inatsu, Toshihiro Kita, Kazuo Kitamura
2019 Internal medicine (Tokyo. 1992)  
A 35-year-old man with refractory Crohn's disease showed a loss of response to infliximab after requiring treatment with infliximab at 10 mg/kg together with steroid to maintain remission. His symptoms recurred, and colonoscopy showed extensive active ulcers in the colon. Adrenomedullin therapy was started in addition to the conventional infliximab therapy. A few days after, his symptoms went into remission. Endoscopy at 2 and 7 weeks revealed significant mucosal remission without steroid
more » ... thout steroid therapy. Adrenomedullin promoted mucosal healing and led to the re-induction of remission in Crohn's disease in a patient with a loss of response to infliximab.
doi:10.2169/internalmedicine.1791-18 fatcat:eooomsjpxrdjvn7hkfgfx4os5a