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The thyroid hormones are protein-bound in the serum, and only 0.02% of T4 and 0.2% of T3 are free, biologically active hormones. 45–70% of thyroid hormones are bound to thyroxine-binding globulin (TBG), and the rest to transthyretin and albumin. Familial conditions, estrogen treatment and pregnancy may have effects on the concentrations of the binding proteins, leading to changes in thyroid hormone fractions until a new equilibrium is reached. Materials and Methods.Thyroid function tests weredoi:10.18535/ijmsci/v5i3.09 fatcat:zhvp66hv7bevjh7okubtg3lybm