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A virtual screening of the ZINC database was applied for the identification of novel cholinesterase inhibitors. The first step allowed to select compounds with favorable physicochemical properties. Then, the compounds were screened with the pharmacophore models built using crystal structures of donepezil, tacrine, decamethonium and bis-7-tacrine with acetylcholinesterase and well characterized interactions of bis-nor-meptazinol with butyrylcholinesterase. The selected compounds from the grouppmid:26647631 fatcat:xnsjlfnydvgz5nheszpvtbfo7a