Hospitalized patients are at an increased risk for acquiring Clostridium Difficile Infection (CDI). Increased virulence of C. difficile strains and increased use of antimicrobials have led to an increase of CDI cases that are more difficult to treat (CDC, 2013). Proper hand hygiene techniques, room cleaning, and equipment cleaning are not consistently being followed by healthcare workers, leading an increased spread of CDI between hospitalized patients. The purpose of this integrative review

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... to determine the best evidencebased methods to reduce hospital-acquired CDI rates. The evidence reviewed supports the implementation of a multifaceted approach including: (a) proper hand hygiene practices, (b) adequate and appropriate surface cleaning practices, (c) compliance to contact isolation procedures, and (d) strengthening of an existing antimicrobial stewardship committee to reduce hospital-acquired CDI rates.