Factor V Leiden G1691A and Prothrombin G20210A mutations are associated with repeated spontaneous miscarriage in Northern area of Saudi Arabia

Fakhr Eldeen, A Badawy, B Abu AlSel, M S Fawzy
2017 Genetics and Molecular Research  
Maternally inherited thrombophilia could be one of the causes of recurrent spontaneous miscarriage (RSM). We aimed to investigate the frequency of three thrombotic gene variants; factor V Leiden (FVL; G1691A), prothrombin (PTH; G20210A), and methylenetetrahydrofolate reductase (MTHFR; C677T) in Saudi patients diagnosed with RSM. A case control study was conducted on 96 RSM patients and 96 age-matched controls. Genotyping was based on polymerase chain reaction followed by hybridization with
more » ... idization with variant-specific oligonucleotide probes using FV-PTH-MTHFR Strip Assay. There was a significantly higher frequency of the AA genotype of FVL in the RSM group when compared to controls (P < A. Fawzy MS, et al.
doi:10.4238/gmr16039810 fatcat:ybqk5i2mp5dcrbd5uxco2ozpb4