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Maternally inherited thrombophilia could be one of the causes of recurrent spontaneous miscarriage (RSM). We aimed to investigate the frequency of three thrombotic gene variants; factor V Leiden (FVL; G1691A), prothrombin (PTH; G20210A), and methylenetetrahydrofolate reductase (MTHFR; C677T) in Saudi patients diagnosed with RSM. A case control study was conducted on 96 RSM patients and 96 age-matched controls. Genotyping was based on polymerase chain reaction followed by hybridization withdoi:10.4238/gmr16039810 fatcat:ybqk5i2mp5dcrbd5uxco2ozpb4