Reiter's Syndrome Associated with HLA-B51

Yuko SHIMAMOTO, Hajime SUGIYAMA, Shunsei HIROHATA
2000 Internal medicine (Tokyo. 1992)  
A22-year-old Japanese mandeveloped polyarthritis with fever and urethritis. He was diagnosed as Reiter's syndrome since he was found to have uveitis and persistent aseptic pyuria. Although, he was negative for HLA-B27or any other HLA-B27cross-reactive MHCclass I antigens, he was positive for HLA-B51. The laboratory examination showed significant elevation of serum IgG and IgA anti-Chlamydia antibodies. He was successfully treated with a combination of doxycycline, naproxen, salazosulfapyridine
more » ... alazosulfapyridine and methotrexate with a decrease in IgG and IgA anti-Chlamydia antibodies. Previous studies provided evidence that HLA-B51 itself might be involved in the development of Beh^et's disease, which shares commonfeatures with Reiter's syndrome, such as uveitis, skin lesions, and polyarthritis. It is therefore suggested that combination of Chlamydia infection and HLA-B51might play a role in the pathogenesis of Reiter's syndromein our patient.
doi:10.2169/internalmedicine.39.182 fatcat:rtuy63qdxffvflkwavz3p6utxy