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The first reversed phase high performance liquid chromatographic method for Stability Indicating of, Azilsartan and chlorthalidone has been developed and validated to be a simple, sensitive, rapid, specific, precise, and accurate method. Chromatographic separation was achieved on Zorbax XBD-C8, 250mm × 4.6mm,5µm.Buffer pH5.5 : Methanol (60:40) as a mobile phase at flow rate of 1 ml/min. UV detection was operated at 234 nm and injection volum was 25 μl.. The proposed method showed gooddoi:10.22270/jddt.v9i4-s.3315 fatcat:v54zrfptcvdsjkvbsfaeoe7vvq