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This paper investigate the determinant of profitability of Islamic banks from the MENA region and how Global Financial Crisis (GFC) impacts on their performance. The study covers 117 banks for periods of 2003 to 2011. To examine the determinant of Islamic banking profitability (ROA), we apply a balanced and dynamic panel data regression model. We conclude that the profitability of Islamic banks in the MENA countries is determined positively by asset size, equity to total asset, liquidity riskdoi:10.24191/jeeir.v4i1.9074 fatcat:k6bndv3lyvcenpsre5it3gnj24