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The North American wood frog, Rana sylvatica, can inhabit extremely cold climates utilizing a variety of adaptions. The purpose of this review was to identify the driving mechanisms behind the overwintering response of R. sylvatica. The major response factors that were found to be instrumental to survival include environmental and behavioral adaptations, internal freezing point depression by increasing blood and tissue concentration of glucose and urea, and reduced metabolic activity bydoi:10.5203/pmuser.201841615 fatcat:xkekk5rgajfcjfgi4kxkkxlwfq