Antidiarrheal activity of aqueous ethanol extract of Cyperus esculentus tuber in albino rats

2020 Journal of Applied Biology & Biotechnology  
Cyperus esculentus is used in the treatment of diarrhea in traditional medicine. Antidiarrheal activity of aqueous ethanol extract of C. esculentus tuber was investigated in albino rats with castor oil induced and charcoal meal assays. Acute toxicity and preliminary phytochemical constituents were determined. Fifty albino rats were divided into five groups of five animals each for each assay. The extract was administered at doses of 250, 500, and 1,000 mg/kg, loperamide at 2 mg/kg, and atropine
more » ... mg/kg, and atropine at 0.1 mg/kg (positive control groups), while 1% tracaganth mucilage was given to negative control group. The LD50 was above 5,000 mg/kg. Phytochemical evaluation indicated the presence of steroids, carbohydrates, alkaloids, and saponins. A non-statistically significant (p > 0.05) decrease in mean weight of wet feces (1.71 ± 1.23 g, 1.75 ± 0.77 g) and mean frequency of watery defecation (1.6 ± 1.03, 1.8 ± 0.97) at 500 and 1,000 mg/kg extract doses. Percentage inhibition of defecation was 46.7% and 40% at 500 and 1,000 mg/kg doses of the extract, respectively, while that of loperamide was 46.7% relative to the negative control in castor oil induced test. The findings have shown that the aqueous ethanol extract of C. esculentus tuber seems to possess anti-secretory effect but does not have anti-motility effect. How to cite this article: Shorinwa OA, Dambani DT. Antidiarrheal activity of aqueous ethanol extract of Cyperus esculentus tuber in albino rats.
doi:10.7324/jabb.2020.80309 fatcat:myg6goitr5amrbi43i6hzt7xse