рииа риа, еорги ооре, ааеиа оореа, ора еооа, е ИИааооа УУивеиие ааиеи е ии, ввив Abstract The influence of phosphorus, inorganic nitrogen, magnesium and potassium sources on lipase production by submerged fermentation from Rhisopus arrhizus was studied by a central composite design 2 4. As a result of planned mathematical experiment an equation was developed which was able to describe the function with high value of the determination coefficient (R 2 =88.48%). When the model was studied the

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... mal concentrations of the salts were predicted as follows, g.dm-3 : NH 4 H 2 PO 4 6.50; (NH 4) 2 C 2 O 4 0.90; MgSO 4 0.95; KCl 0.95. Maximum lipase activity was 4200.08 U.dm-3 according to the model. Three consecutive experiments at the predicted optimal values of the factors were carried out and a mean value of 3980.90 U.dm-3 enzyme activity was achieved. The obtained activity was very close to the predicted one which means that this model correctly described the examined process.