Focal Acral Hyperkeratosis with Intracorneal Retention of Keratohyalin Granules

2017 ARC Journal of Dermatology  
Acrokeratoelastoidosis (AKE) and focal acral hyperkeratosis (FAH) are rare genodermatoses with many shared clinical and histopathologically features, distinguished solely by the absence of elastorrhexis in FAH. We present a case of FAH in a 42-year-old woman with HIV-HVB co-infection that showed multiple skin-colored papules with central umbilication on the sides and dorsum of both hands and feet, without nail involvement. Histology showed compact hyperkeratosis with retention of
more » ... n of intracytoplasmic basophilic keratohyalin granules and no dermal elastorrhexis. Retention of keratohyalin granules could relate to a primary defect of cornification in patients with FAH and, if reproducible, could potentially serve as a histopathological discriminator from AKE.
doi:10.20431/2456-0022.0201005 fatcat:o34fh5arnreetppmoamgutiqwu