Traditional system of healing that originated in South India and considered to be one of Indian's oldest systems of medicine. The Siddha system of medicine described about 32 forms of internal medicines in Siddha text. Among these forms, Chendooram is the one form of internal medicine. The aim of this drug review is to validate the Siddha meto- mineral formulation Kadikara chendooram with scientific evidences. The medicinal uses and therapeutic actions of the part of each ingredient used in

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... formulation matched with current research findings from various research publications. Through this extensive review on Siddha and recent research reports minimal scientific validation has been carried out on various pharmacological actions and therapeutic benefits of each ingredient of Kadikara chendooram. The ingredients present in this formulation have effective in the treatment of Hemiplegia and diarrhea / dysentery. Based on this evidence of Siddha literature and the modern scientific research studies also provide keyhole which result are Anti-Platelet aggregation, Thrombolytic, Anti-diarrhoeal, Antimicrobial activities most presents in ingredient of Kadikara chendooram as evident from the current review. Key words: Kadikara chendooram, Hemiplegia, Siddha system.