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The paper employs a regional innovation system concept and divides system failures into three categories: institutional infrastructure, organizational landscape and structural connectedness. To analyze the economic effects of systemic interventions, it employs the VISIBLE model, which allows ex-ante policy experiments to be conducted in a virtual simulation environment. First, the findings show that regional learning and knowledge exchange are accompanied by pronounced non-linearities anddoi:10.6084/m9.figshare.7687391 fatcat:ye44iowq4jgbpi6vqif3xzysza