Original Article Comparison of gadoxetic acid disodium-enhanced MRI and biphasic spiral CT in detection of hepatocellular carcinoma in patients meeting the Milan criteria

Wenjie Tang, Jie Qin, Bing Hu, Lina Zhang, Ruomi Guo, Jin Wang
2018 Int J Clin Exp Med   unpublished
Objective: To prospectively compare gadoxetate disodium-enhanced MRI with biphasic spiral CT in the detection of HCC in patients within the Milan criteria. Methods: The study was designed as a prospective, open-label, within-patient with a corresponding blinded reading. AUCs were also applied to compare for the comparison of combined unenhanced and gadoxetic acid disodium-enhanced MRI versus biphasic spiral CT using the Hanleyand McNeil method. Results: For all liver lesions meeting Milan
more » ... meeting Milan criteria, the diagnostic accuracy across the three readers was significantly greater with Gadoxetic acid disodium-enhanced MR imaging than with biphasic spiral CT. The AUC of GAD enhanced MRI were 0.873 with 95% CI = 0.801-0.925, 0.928 with 95% CI = 0.869-0.967 and 0.854 with 95% CI = 0.780-0.911 respectively in Reader 1, 2, and 3. The AUC of biphasic spiral CT were 0.724 with 95% CI = 0.638-0.800, 0.705 with 95% CI = 0.617-0.783 and 0.669 with 95% CI = 0.580-0.751 respectively in Reader 1, 2, and 3. The sensitivity across the three readers was significantly greater with Gadoxetic acid disodium-enhanced MR imaging than with biphasic spiral CT. Average across Readers were 0.851 with 95% CI = 0.745-0.962 vs. 0.692 with 95% CI = 0.596-0.793, respectively. Conclusion: Compared with biphasic spiral CT, Gadoxetic acid disodium-enhanced MRI yields significantly higher diagnostic accuracy and sensitivity in the detection of HCC in patients within Milan criteria.
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