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<p><i>Mycobacterium tuberculosis</i>, the organism responsible for TB infection in humans, is inherently resilient against host defences and anti-TB drugs. This persistence is attributed partly to the presence of lipids, such as mycolic acids (MAs), which make the cell wall impermeable. To study the conformational dynamics of MAs, we present a coarse-grained model for a representative α-MA (AMA) from <i>Mycobacterium tuberculosis</i>using the MARTINI force field. The model is used to simulatedoi:10.26434/chemrxiv.7881215.v1 fatcat:2g42amfs2vfc7lrrwpf6kjdkku