Cytokine profile associated with chronic and acute human schistosomiasis mansoni

Clarice Neuenschwander Lins de Morais, Joelma Rodrigues de Souza, Wlademir Gomes Melo, Marcílio L Aroucha, Paulo Miranda, Ana Lúcia Coutinho Domingues, Frederico Guilherme Coutinho Abath, Silvia Maria Lucena Montenegro
2008 Memórias do Instituto Oswaldo Cruz  
The production and regulation of interleukin (IL) was evaluated in 43 schistosomiasis patients with different clinical forms. Whole-blood cultures cytokine production in response to soluble egg antigen (SEA), soluble worm adult preparation (SWAP), mitogens, neutralizing antibodies or recombinant IL-13 were measured by ELISA. After SWAP stimulation, chronic patients, particularly hepatointestinals, produced higher levels of IL-4 in comparison with acute patients, suggesting the presence of a
more » ... e presence of a type 2 cytokine profile in these patients. Following SEA and SWAP stimulation, hepatosplenic (HS) patients showed increased levels of IFN-γ when compared with acute patients, indicating that HS disease in humans is associated with a type 1 cytokine response. The mechanisms of immune regulation are apparently different between the clinical stages of the disease, some of which are antigen-specific.
doi:10.1590/s0074-02762008000600009 pmid:18949326 fatcat:yb27iei2tvaelgkecdtgrkv4gq