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Mapping protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry
2010
Methods
Voxelation creates expression atlases by high-throughput analysis of spatially registered cubes or voxels harvested from the brain. The modality independence of voxelation allows a variety of bioanalytical techniques to be used to map abundance. Protein expression patterns in the brain can be obtained using liquid chromatography (LC) combined with mass spectrometry (MS). Here we describe the methodology of voxelation as it pertains particularly to LC-MS proteomic analysis: sample preparation,
doi:10.1016/j.ymeth.2009.07.009
pmid:19654045
pmcid:PMC2818068
fatcat:7xs4jckzw5grthashdma62ttvi