Evaluation of temperature sensitivity of human papillomavirus type 11 by using the human xenograft severe combined immunodeficiency mouse model

W Bonnez, R C Rose, C Borkhuis, C Da Rin, R C Reichman
1994 Journal of Clinical Microbiology  
The temperature sensitivity of human papillomavirus type 11 was evaluated by using a human xenograft severe combined immunodeficiency mouse model. Incubation of the virus for 1 h at a temperature higher than 56°C but lower than 72°C was sufficient to inhibit the virally induced growth of infected human tissue. However, 100°C was necessary to completely inactivate HPV type 11 genome expression.
doi:10.1128/jcm.32.6.1575-1577.1994 fatcat:padcoujsnvbihivh266cltmk7i