Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone

S. Kalhor-Monfared, M. R. Jafari, J. T. Patterson, P. I. Kitov, J. J. Dwyer, J. M. Nuss, R. Derda
2016 Chemical Science  
In this manuscript, we describe modification of Cys-residues in peptides and proteins in aqueous solvents via aromatic nucleophilic substitution (SNAr) with perfluoroarenes (fAr).
doi:10.1039/c5sc03856a pmid:30155020 fatcat:dz27inobzzfa3kvhmjmzbd3tvm