Phylogenetic analysis and In silico Screening of drug targets for ACE2 in Human and Spike Glycoprotein in Sars-CoV-2 for control of COVID19 [post]

Kaladhar SVGK Dowluru, Krothapalli. R. S. Sambasiva Rao
2020 unpublished
Coronaviruses are the large group of infectious viruses that affect the respiratory tract and damages lungs. Large part to early Chinese efforts to genome sequencing of Sars-CoV-2, the virus that causes the Covid-19 disease, shared in early January 2020. The sequences from Wuhan seafood market pneumonia virus had different point mutations and are showing non-conserved patterns in between sequences from different regions of world. The present experimentation has shown that bioactive compounds
more » ... active compounds like Nimbin present in Neem plant and Amlaic acid present in Amla are shown as best in the control COVID19. The bioactive compounds like Vitexin present in Bermuda grass and Curcumin present in turmeric powder were also shown good results. Hence usage of Neem, Amla, Bermuda grass and turmeric can boosts immunity and control COVID19. In anti-viral compounds, Remdesivir was found best and effective drug. Lopinavir also find effective drug next to Remdesivir. Hence in higher conditions, combination of remdesivir and lopinavir may be the best way of treatment for COVID19 patients. As antiviral compounds have side effects, Nimbin, Amlaic acid, Vitexin or Curcumin may be better molecules in the treatment of COVID19.
doi:10.21203/rs.3.rs-23862/v1 fatcat:jfkkqljyjvcn3dyuwhorids4oa