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Holograms of colloidal particles can be analyzed with the Lorenz-Mie theory of light scattering to measure individual particles' three-dimensional positions with nanometer precision while simultaneously estimating their sizes and refractive indexes. Extracting this wealth of information begins by detecting and localizing features of interest within individual holograms. Conventionally approached with heuristic algorithms, this image analysis problem can be solved faster and more generally withdoi:10.1364/oe.26.015221 pmid:30114772 fatcat:vq4xhm625za77govazox2zgmsy