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There is a renewed interest in computer-aided synthesis planning, where the vast majority of approaches require the application of retrosynthetic reaction templates. Here, we introduce an open source Python wrapper for RDKit designed to provide consistent handling of stereochemical information in applying retrosynthetic transformations encoded as SMARTS strings. RDChiral is designed to enforce the introduction, destruction, retention, and inversion of tetrahedral centers as well as thedoi:10.26434/chemrxiv.7949024.v1 fatcat:l7iekch2argjrgbgru4l3rkgse