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Neutron scattering exploits the enormous scattering difference between protons and deuterons. A set of 42 x-ray and neutron solution scattering curves from hybrid Escherichia coli ribosomes was obtained, where the proteins and rRNA moieties in the subunits were either protonated or deuterated in all possible combinations. This extensive data set is analyzed using a novel method. The volume defined by the cryoelectron microscopic model of Frank and co-workers (. (1995) Nature 376, 441-444) isdoi:10.1074/jbc.275.19.14432 pmid:10799526 fatcat:iompv27kzba6ja626oldvfn3ca