Undiagnosed Collecting Duct Carcinoma Presenting as Meningeal Carcinomatosis and Multiple Bone Metastases

Shunsuke Ohnishi, Masayoshi Dazai, Yoshinori Iwasaki, Kazufumi Tsuzaka, Tatsuro Takahashi, Takuto Miyagishima
2010 Internal medicine (Tokyo. 1992)  
A 54-year-old woman presented with blepharoptosis, numbness in the lower lip, dysgeusia and pain in the extremities and back. MRI showed marked meningeal thickening and multiple bone lesions accompanying a prominent enhancing effect. CT scan of the chest and abdomen appeared to be unremarkable for primary cancer. She died 3 months after the admission, and postmortem autopsy showed a mass of about 2.5 cm in diameter in the renal medulla. Histological examination including immunohistochemistry
more » ... nohistochemistry confirmed the presence of a collecting duct carcinoma (CDC). This case is of particular interest because it emphasizes the possible fulminate clinical course of a small CDC.
doi:10.2169/internalmedicine.49.3427 pmid:20686287 fatcat:nvqnjlbvgnfurbbjqysxkcy4be