Advanced Regenerative Techniques Based on Dental Pulp Stem Cells for the Treatment of Periodontal Disease [chapter]

Ana-Maria Seciu, Oana Craciunescu, Otilia Zarnescu
2019 Periodontology and Dental Implantology  
Recent progress in periodontology intended to reduce the risk represented by periodontal disease for systemic disorders and general human health condition. In this chapter, we overview the advantages and limitations of current techniques based on occlusive membranes for periodontal regeneration. Special emphasis is paid to advanced techniques using stem cells from dental pulp for the regeneration of bone defects caused by the chronic periodontal disease. Stem cells isolation, in vitro expansion
more » ... in vitro expansion and characterization techniques are presented. Therapeutic strategies of stem cells delivery using natural polymeric carriers are discussed. Stem cell-scaffold constructs application in bone tissue engineering is proposed, taking into account the marked decline of healing, and regenerative processes in elderly individuals. Future researchers envisage multiple effects of engineered constructs with antimicrobial, anti-inflammatory, and regenerative activity for periodontal treatment.
doi:10.5772/intechopen.78048 fatcat:46pznz73sndtzokli5wkqzktye