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This study describes cases of syphilis in pregnancy (SiP) and congenital syphilis (CS) and identifies factors associated with mother-to-child transmission in patients in Itapeva from January 1, 2010 to December 31, 2014. Using SiP and CS notification forms and medical records, a cross-sectional study involving 149 pregnant women was conducted. Annual SiP detection rates ranged from 16.3-31.4/1000 live births. Most women had prenatal care started at the first trimester of pregnancy with ≥6doi:10.1590/0037-8682-0377-2017 pmid:30517537 fatcat:fqsw3sgnnfdihnb4a3ghhdq45e