Hypothesis on a signalling system based on molecular vibrations of structure forming macromolecules in cells and tissues
Integrative Molecular Medicine
Cells and tissues are tree-dimensional systems. The scaffolds are established by macromolecules such as proteins, polar lipids, glucosaminoglycans, glycoproteins, cholesterol forming networks and membranes. These structures are permanently changed, remodelled, restored. The chemical signalling is insufficient to inform on spatial aspects where changes are needed and it should be supplemented by physical signals. All molecules show molecular vibrations at the temperature of living systems. This
... ving systems. This oscillation of macromolecules creates infrared radiation. As the molecules carry functioning groups the infrared radiation is characterised by defined peaks. Frequencies of mid-infrared spectrum below 1300 cm-1 can penetrate without being weakened by water absorption. The peaks are modified by the specific environment of the molecule and change in the course of chemical reactions. If the cells responsible for supply of restoring or remodelling enzymes are capable to realize these signals the spatial aspects can be verified. The hypothesis presented is that these cells develop receptors at the cell membrane, and at the nuclear envelope for intracellular actions, based on resonance principle to record and process these signals. The cell membrane is a barrier for intracellular signals to avoid disturbance of adjacent cell. The interaction between tissue cells and their extracellular matrix in developing organism are very intensive. Signalling based on molecular vibration could be important in the memory process as well. If the information unit is stored as a modified macromolecule the specific changed vibration signal could be retrieved by the dendrite spine of the neurone after depolarisation. The retrieval process would not change the stored information unit and would be very energy efficient. The neurone represents the active part of storage and retrieval. If the hypothesis is experimentally proved a high amount of new research activities are induced up to new applications in stem cell research, cancer research, therapeutic possibilities, plant research.