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The demethylation of methylmercury (MeHg) was investigated in human neuroblastoma, glioblastoma and liver cells. In the three cell lines, MeHg uptake reached a plateau within 24 hr after MeHg exposure while the cellular inorganic Hg levels increased gradually up to 72 hr. Methylviologen, a superoxide anion (O − 2 ) generator, was found to be an effective enhancer of demethylation with only a minor effect on lipid peroxidation in all three cases. Fe(II), a hydroxyl radical (OH·) enhancer, showeddoi:10.1248/jhs.56.326 fatcat:4nrbev6ivfhpxpuwuzrd6jcoxq