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A 30-year-old man, whohad a repeated history of relapsed Hodgkin's lymphoma over 7 years, developed bilateral pleural effusion and chest wall involvement. He was treated with weekly irinotecan hydrochloride (CPT-ll ; 80 mg/m2/week). Partial response was observed after two cycles of irinotecan. Neutropenia and diarrhea were tolerable. This case demonstrated that irinotecan has a therapeutic effect in patients with relapsed Hodgkin's lymphoma. (Internal Medicine 41 : 648-650, 2002)doi:10.2169/internalmedicine.41.648 fatcat:5pmoijlvpbgvvou3qv3vmlj7pe