Food for thought … on in silico methods in toxicology

Thomas Hartung
2009 ALTEX: Alternatives to Animal Experimentation  
this series of articles has already addressed in vitro and in vivo tools (Hartung, 2007; Hartung, 2008b) . With this contribution addressing computational toxicology we now try to complete considerations on the main methodological approaches in toxicology. However, we do still plan to address specific aspects, such as endpoints (omics, image technologies), high-throughput testing or physiology-based pharmaco-(toxico-)kinetic modelling (PBPK), in later issues. All of these aspects have major in
more » ... ects have major in silico components, which already shows how difficult it is to discuss in silico methods on their own. Indeed, their integration and interplay with in vivo and in vitro approaches is critical, at least in the way their development often depends critically on the input of either in vitro or in vivo data. this is a major difference to experimental approaches. An important consideration will thus be whether in silico methods are limited by the limitations of their input and whether we have any hope of overcoming their weaknesses or can only approximate them... there are some excellent introductions to and reviews of
doi:10.14573/altex.2009.3.155 fatcat:jtyml4jjy5c4li4ijwhg34g5ui