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this series of articles has already addressed in vitro and in vivo tools (Hartung, 2007; Hartung, 2008b) . With this contribution addressing computational toxicology we now try to complete considerations on the main methodological approaches in toxicology. However, we do still plan to address specific aspects, such as endpoints (omics, image technologies), high-throughput testing or physiology-based pharmaco-(toxico-)kinetic modelling (PBPK), in later issues. All of these aspects have major indoi:10.14573/altex.2009.3.155 fatcat:jtyml4jjy5c4li4ijwhg34g5ui