cDNA Microarray Gene Expression Analysis and Toxicological Phenotype for Anticancer Drug

Gyoung-Jae LEE, Wan-Seon LEE, Ki-Seon JEON, Chan-Hwi UM, Yang-Suk KIM, Seung-Jun KIM, Chang-Hyeon LEE, Hyun-Kyu YOON, Seung Yong HWANG, Joon-Suk PARK, Jae-Woong HWANG, Kyung-Sun KANG (+5 others)
2004 Journal of Veterinary Medical Science  
Toxicogenomics, the subdiscipline that merges genomics with toxicology, hold the promise to contributing toward the goal of elucidating mechanism by studying genomic profiling related with various drugs. The application of gene expression profiling technology to examine multiple genes and signaling pathways promises a significant advance in understanding the toxic mechanisms of var ious drugs and prediction of new drug candidate. Toxicogenomics is emerging field combining genomics and
more » ... omics and bioinformatics to identify and characterize mechanisms of toxicity of drug and various compounds. The principal hypothesis underlying on this field is that ch emicalspecific pattern of altered gene expression is related with each chemicals properties, especially toxicological property, and it will be revealed using high-density microarray analysis of sample from exposed organisms. So, in this study we compare the gene expression pattern of two anticancer drugs paclitaxel and orally absorbable paclitaxel, using the cDNA microarray. And from the result of this study, it is possible to provide the new possibility for genome-wide insight into mechanism of their anticancer activity and toxicological phenotype. KEY WORDS: anti-cancer agent, cDNA microarray, orally absorbable paclitaxol, paclitaxel, toxicogenomics.
doi:10.1292/jvms.66.1339 pmid:15585946 fatcat:qzzgqjxmzvdcxfp7nwszbssnse