1916 Archives of internal medicine (Chicago, Ill. : 1908)  
The uncertainty that exists in regard to the large mononuclear white blood cells is probably in large part due to the diverse forms they present with the usual stains, and the scarcity of each of these forms in normal blood. The several distinct types represented in this group do not have constant morphologic characteristics demonstrable by the usual stains that admit of a differential classification among them; and only occasionally is a case encountered in which one type stands out
more » ... ands out predominantly.1 Similarly the mononuclear wandering cells of the tissues, intimately associated with the mononuclear cells of the blood, are seen in many different forms, and although widely distributed throughout the body, each form is encountered alone in appreciable numbers only in rare pathologic conditions. The relations obtaining among these different mononuclear cells of the blood and tissues is, therefore, in some confusion and the status of each uncertain. Some of these cells, the so-called transitionals, stand out from all the rest by reason of their content in granules of oxydase ferment, as demonstrable by the indophenol-blue reaction ; and some may be recognized wherever encountered by their ability to take vital stains. It has seemed that advantage might be taken of these biologic reactions in clearing up the confusion that exists as to the identity of the different types of mononuclear cells in the blood and tissues. The following study was undertaken with this end in view. The different forms presented by the mononuclear cells of the blood and tissues has caused a wide variation in nomenclature for cells, many of which are probably identical or closely related to each other, and this tends to deprive us of the advantage of cumulative observation by different authors. But much work has been done, and in view of
doi:10.1001/archinte.1916.00080180137006 fatcat:7bslivhajvdynbodi4edlfrhuq