Architecture, constraints, and behavior

J. C. Doyle, M. Csete
2011 Proceedings of the National Academy of Sciences of the United States of America  
This paper aims to bridge progress in neuroscience involving sophisticated quantitative analysis of behavior, including the new use of robust control, with other relevant conceptual and theoretical frameworks from systems engineering, systems biology, and mathematics. Familiar and accessible case studies are used to illustrate concepts of robustness, organization, and architecture (modularity and protocols) that are central to understanding complex networks. These essential organizational
more » ... es are hidden during normal function of a system, but fundamental for understanding the nature, design, and function of complex biologic and technologic systems.
doi:10.1073/pnas.1103557108 pmid:21788505 pmcid:PMC3176601 fatcat:d3yqzs3oxrbl5e635kvsgcd74a