Humoral Hypercalcemia of Malignancy in Female F344 Rats Implanted with a Transplantable Rat Pulmonary Carcinoma Line (IP)

Masako NAKANISHI, Jyoji YAMATE, Mika IDE, Osamu SAWAMOTO, Mitsuru KUWAMURA, Takao KOTANI, Shunji NAKATSUJI
2001 Journal of Veterinary Medical Science  
A transplantable rat pulmonary carcinoma line (IP) in F344 rats is a useful animal model for humoral hypercalcemia of malignancy (HHM). The present study analyzed the degree of HHM by implanting IP into F344 female rats aged 6, 20 or 45 weeks. IPbearing females developed elevated plasma parathyroid hormone-related protein levels, hypercalcemia and increased osteoclastic activity as well as calcification in various organs. The severity of such HHM differed depending on age; particularly,
more » ... rticularly, calcification showed agedependent reduction. HHM development in IP-bearing females may be influenced by age-related factors. KEY WORDS: age-dependent factor, humoral hypercalcemia of malignancy, pulmonary rat carcinoma.
doi:10.1292/jvms.63.1135 pmid:11714032 fatcat:cvkyd6wiuzgmvnoo3ok6o2zhfm