Prevalence, Distribution and Antimicrobial Susceptibility Pattern of Bacterial Isolates from a Tertiary Hospital in Malawi [post]

Master Chisale, Pizga Kumwenda, Emmanuel C. Adukwu, Ebot S. Tabe, Victor C Ujor, Pocha S. Kamudumuli, Maono Ngwira, Joseph Wu
2020 unpublished
BackgroundBacterial infections are a significant cause of sickness and death in sub-Saharan Africa. This study aimed at establishing the prevalence, distribution and antimicrobial susceptibility pattern of major bacterial isolates from patients attending a tertiary hospital in Malawi. MethodsWe retrospectively reviewed bacteria culture and antibiotic sensitivity records for 4,617 patients from 2002 to 2014 at Mzuzu Central Hospital (MCH). No inclusion and exclusion criteria were followed. Data
more » ... ere followed. Data was analysed using excel and SPSS programs. ResultsThe most prevalent isolates were S. aureus (34.7%, n= 783), Klebsiella species (17.4%, n= 393) and Proteus species (11.4%, n = 256). Most pathogens were isolated from adults (88.3%, n=3889) and pus was the main source (69.3%, n = 1224). S. pneumoniae was predominantly isolated from cerebrospinal fluid (60.3%, n = 44) largely collected from children (88.2%, n =64). Overall, most bacteria exhibited high resistant to all regularly used antibiotics excluding ciprofloxacin. ConclusionsOur report demonstrates an increase in bacteria burden in sites other than the blood stream and subsequent increase in prevalence of antimicrobial resistance for all major isolates. Creating an epidemiological survey unit at MCH will be essential to help inform better treatment and management options for patients with bacterial infections.
doi:10.21203/rs.3.rs-36411/v1 fatcat:mjvwkg6pfnd3nctdv5ufk27huq