The Left Hemisphere's Structural Connectivity for the Inferior Frontal Gyrus, Striatum, and Thalamus, and Intra-Thalamic Topography

Simone Roberts
2017
The neuroanatomy of language cognition has an extensive history of scientific interest and inquiry. Over a century of behavioral lesion studies and decades of functional neuroimaging research have established the left hemisphere?s inferior frontal gyrus (IFG) as a critical region for speech and language processing. This region?s subcortical projections are thought to be instrumental for supporting and integrating the cognitive functions of the language network. However, only a subset of these
more » ... ojections have been shown to exist in humans, and structural evidence of pars orbitalis? subcortical circuitry has been limited to non-human primates. This thesis demonstrates direct, intra-structural connectivity of each of the left IFG?s gyral regions with the thalamus and the putamen in humans, using high-angular, deterministic tractography. Novel processing and analysis methods elucidated evidence of predominantly segregated cortical circuits within the thalamus, and suggested the presence of parallel circuits for motor/language integration along the length of the putamen.
doi:10.57709/11169917 fatcat:6lbpewdub5ebvpq2g6vmcscwa4