The effect of pentoxifylline on cerebral vasospasm following experimental subarachnoid hemorrhage
International Journal of Neuroscience
Objects: Cerebral vasospasm is an important event that occur following subarachnoid hemorage which has significant mortality and morbidity. The goal in this study was to investigate the effect of pentoxifylline on vasospasm in an experimental subarachnoid hemorrhage model.Methods: In this study 20 male New Zeland White rabbits weighing 3000 to 3500 gr were assigned randomly to four groups. Animals in group 1 served as controls. Animals in group two received only intravenous pentoxifylline
... ion 3 times in 12 hour intervals. In group 3, SAH was induced and no injection was given. Animals in group 4 received intravenous pentoxifylline (6 mg/kg) injections 3 times at 12th, 24th and 36th hours after subarachnoid hemorrhage induction. All animals were sacrificed and basilar arteries were removed at 48th hour. Basilar artery vessel diameters, wall thicknesses and luminal section areas were measured with Spot for Windows version 4.1. Statistical analysis were performed using ANOVA and Kruskall-Wallis tests.Results: Mean basilar artery luminal section areas and luminal diameters in group 4 were significantly higher compared to group 3 (p< 0.05). Basilar artery wall thicknesses and were found to be higher in group 3 than in other groups and this was also statistically significant (p< 0.05).Conclusion: Our study demonstrated that intravenous administration of pentoxifylline significantly decreases vasospasm after subarachnoid hemorrhage.