Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin

Slobodanka Jovanovic, Milanka Vico-Stevanovic, Dragana Ugljesic-Kilibarda, Dragica Popadic, Slobodanka Simic, Dijamanda Dzeletovic
2006 Journal of the Serbian Chemical Society  
Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant, 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)-2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as an
more » ... drochloride as an active pharmaceutical ingredient.
doi:10.2298/jsc0609867j fatcat:xfl6fzitwjdx5kjm32pqyagjaq