A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is
Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant, 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)-2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as andoi:10.2298/jsc0609867j fatcat:xfl6fzitwjdx5kjm32pqyagjaq