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The airway responsiveness to bradykinin (0.1, 1 and 10 µg/kg, i.v.) was examined in two lines of guinea pigs, BHS (bronchial hypersensitive) and BHR (bronchial hyposensitive) lines, with different airway sensitivity to inhalation of acetylcholine (ACh)-aerosol. Normal Hartley strain guinea pigs were used as a control group. The airway contraction was measured by recording intratracheal pressure (P IT ) and respiratory airflow (V) under the condition of artificial ventilation in anesthetizeddoi:10.1292/jvms.59.613 pmid:9271461 fatcat:6ouhuinvq5fufgtfura6dmibxi