Bradykinin-Induced Airway Contraction in Two Lines of Guinea Pigs with Congenitally Different Airway Sensitivity

Hirokazu TSUBONE, Shinichi SEKIZAWA, Masashi MAEDA, Masayoshi KUWAHARA, Junichi BIRUMACHI, Shigeru SUGANO, Ryoji NISHIBATA, Hiroki MIKAMI
1997 Journal of Veterinary Medical Science  
The airway responsiveness to bradykinin (0.1, 1 and 10 µg/kg, i.v.) was examined in two lines of guinea pigs, BHS (bronchial hypersensitive) and BHR (bronchial hyposensitive) lines, with different airway sensitivity to inhalation of acetylcholine (ACh)-aerosol. Normal Hartley strain guinea pigs were used as a control group. The airway contraction was measured by recording intratracheal pressure (P IT ) and respiratory airflow (V) under the condition of artificial ventilation in anesthetized
more » ... in anesthetized guinea pigs. The results show airway responsiveness to bradykinin in BHS guinea pigs to be significantly greater than in BHR and normal Hartley strain guinea pigs. -KEY WORDS: bradykinin, bronchoconstriction, guinea pig.
doi:10.1292/jvms.59.613 pmid:9271461 fatcat:6ouhuinvq5fufgtfura6dmibxi