EVALUATION OF ANTI CATALEPTIC ACTIVITY FOR METHANOLIC EXTRACT OF AERVA LANATA WHOLE PLANT

Sneha Nawale 1 *, P. Pranusha1, K. Padma Priya1, M. Ganga Raju 2
2019 Zenodo  
The present study was done to evaluate the anti-cataleptic activity for methanolic extract of Aerva lanata whole plant (MEAL) in haloperidol induced catalepsy (HIC) and clonidine induced catalepsy (CIC) in mice. Catalepsy was induced by administering haloperidol (1.0 mg/kg bd.wt, i.p.) and clonidine (0.5 mg/kg, bd.wt, s.c.) daily for 21 days. The anti-cataleptic effect of Aerva lanata was evaluated by standard bar test, locomotor activity, rota rod test, and cook's pole climbing test in mice
more » ... ing test in mice models. Results were analyzed by one-way ANOVA followed by Dunnett's test. MEAL (200 and 400 mg/kg bd.wt., p.o.) was found to decrease the duration of catalepsy significantly (P < 0.01) in standard bar test, significantly increases (P < 0.01) basal activity score in locomotor activity and fall-off time in rota rod test respectively, when results were compared to clonidine group in CIC. MEAL (200 mg/kg bd.wt., p.o.) showed more potent anti-cataleptic activity than MEAL (400 mg/kg bd.wt., p.o.). Anti-cataleptic activity of MEAL might be due to presence of flavonoids, alkaloids and other secondary metabolites. Further studies are proposed to prove the anti-cataleptic activity with isolated secondary metabolites at receptor levels. KEYWORDS: Catalepsy; Aerva lanata; Amaranthaceae; Haloperidol; Clonidine; Levodopa; Carbidopa.
doi:10.5281/zenodo.3365636 fatcat:dquddi2l3bcjlgjsjgluoz7264