Home Parenteral Nutrition in Patients with Intestinal Failure: Possible Undetected Complications

Lidia Santarpia, Giulio Viceconte, Maria Foggia, Lucia Alfonsi, Grazia Tosone, Luigi Camera, Maria Pagano, Giuseppe De Simone, Franco Contaldo, Fabrizio Pasanisi
2019 Nutrients  
Septic pulmonary embolism (SPE) may be a frequently undetected complication of central venous catheter (CVC)-related bloodstream infections (CRBSIs). Materials and Methods: The incidence of SPE was evaluated in a cohort of non-oncological patients on home parenteral nutrition (HPN) who were hospitalized for a CRBSI from January 2013 to December 2017. The main clinical, microbiological, and radiological features and the therapeutic approach were also described. Results: Twenty-three infections
more » ... -three infections over 51,563 days of HPN therapy were observed, corresponding to an infection rate of 0.45/1000. In 10 out of the 23 cases (43.5%), pulmonary lesions compatible with SPE were identified. Conclusion: Our results demonstrated that a CRBSI can produce asymptomatic SPE with lung infiltrates in 43.5% of the cases, suggesting the need to check for secondary lung infections to choose the most appropriate antimicrobial therapy.
doi:10.3390/nu11030581 fatcat:f7fe5u2bbjhapk4u7hlgl32zim