Host- Guest Interaction Of 3-(4-Chlorophenyl)-1-Cyclopropyl-2-(2-Fluorophenyl)-5-(4-Fluorophenyl) Pentane-1, 5-Dione: Β-Cyclodextrin Inclusion Complex

T. R. Ragi, H. Manikandan, K. Sivakumar
2017 Zenodo  
The inclusion complex of 3-(4-chlorophenyl)-1-cyclopropyl-2-(2-fluorophenyl)-5-(4-fluorophenyl) pentane-1, 5-dione (CFPD) and β-Cyclodextrin (β-CD) has been investigated using UV and fluorescence spectroscopic techniques. The binding constant and 1:1 stoichiometry of the inclusion complex were determined using Benesi- Hildebrand plots. 1:1 stoichiometry for CFPD: β-CD has been confirmed by Job's plot. The thermodynamic parameter (ΔG) of inclusion process was determined. The formation of the
more » ... ormation of the inclusion complex between CFPD and β-CD, was further confirmed by molecular docking studies are in good relationship with the results obtained through experimental methods.
doi:10.5281/zenodo.256299 fatcat:jsfq7ux7wrecdokrcn3nhealoi